Browsing by Author "Aguillón Gutiérrez, Juan Carlos"

Now showing items 1-20 of 23

    • Actividad angiogénica y apoptónica en la artritis murina inducida con colágeno bovino tipo II 
      Abello Cáceres, Paula (Universidad de Chile, 2007)
      La artritis reumatoide es una enfermedad autoinmune sistémica crónica que se caracteriza por presentar hipertrofia de la membrana sinovial, formando un tejido de granulación llamado pannus, el que invade y destruye hueso ...
    • An anti-human recombinant tumor necrosis factor alpha (TNFα) monoclonal antibody recognizes an epitope in ... 
      Aguirre, Adam; Escobar, Alejandro; Ferreira, Viviana; Molina, María C.; Ferreira, Arturo; Aguillón Gutiérrez, Juan Carlos (EDP Sciences, 2003)
      It is likely that the murine response to human recombinant TNFα (hrTNFα) may generate antibodies (Ab) to epitopes present in TNFα from other species. Here, we demonstrate that F5 anti-hrTNFα monoclonal antibody (mAb) ...
    • An immunogenetically defined and immunodominant Trypanosoma cruzi antigen 
      Ramos Ramos,Fernanda C.; Juri,; Hoecker, G.; Lavandero González, Sergio; Pena,; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Aguillón Gutiérrez, Juan Carlos; Ferreira e Ferreira, Efigenia (1991)
      Two strains of mice, A. SW (H-2(s)) and A.CA (H-2(f)), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from ...
    • Anticuerpos policlonales antiinmunoglobulinas de salmón; herramientas potenciales para diagnóstico 
      Aguillón Gutiérrez, Juan Carlos; Smith, P.; Colombo, A.; Molina, M. C.; Ferreira, A. (1997)
      Immunoglobulins (Igs) from sera of Atlantic salmon (Salmo salar) were purified with 50% saturated ammonium sulphate followed by molecular sieving chromatography using Sephacryl S-300. The fraction of purified Igs was used ...
    • B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, ... 
      Catalán Martina, Diego; Aravena, Octavio; Sabugo, Francisca; Wurmann, Pamela; Soto, Lilian; Kalergis, Alexis M.; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos (2010)
      Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
    • Células dendríticas inductoras de una respuesta tolerogénica 
      Aravena Madariaga, Octavio Alexis (Universidad de ChilePrograma Cybertesis, 2006)
      Las células dendríticas (DC) son células presentadoras de antígeno (APC) profesionales que juegan un papel principal en la iniciación de la respuesta inmune primaria y secundaria. Se encuentran en distintos estados ...
    • Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and ... 
      Hager Ribeiro, Carolina; Kramm, Karina; Gálvez Jirón, Felipe; Pola, Víctor; Bustamante Zamorano, Marco; Contreras Muñoz, Héctor; Sabag, Andrea; Garrido Tapia, Macarena; Hernández, Carolina; Zúñiga, Roberto; Collazo, Norberto; Sotelo, Pablo Hernán; Morales, Camila; Mercado, Luis; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos; Molina, María Carmen (Spandidos Publ. Ltd., 2016)
      Gastric cancer (GC) is the third most common cause of cancer death worldwide. Natural killer cells play an important role in the immune defense against transformed cells. They express the activating receptor NKG2D, whose ...
    • Evaluación de la producción de IL-10 y de la expresión de FcyRllb en linfocitos B de pacientes con ... 
      Ferrier Esposito, Ashley Andrés (Universidad de Chile, 2016)
      La Esclerosis Sistemica (ES) es una enfermedad autoinmune caracterizada por una fibrosis extensiva en la piel y en órganos internos. Actualmente la fisiopatología de esta enfermedad permanece desconocida, sin embargo ...
    • How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis 
      Soto, Lilian; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos; Cuchacovich Turteltaub, Miguel (Future Medicine Ltd., 2015)
    • Humoral immune response anti K99 pilus from enterotoxigenic Escherichia coli in experimentally inoculated calves 
      Bustos,; Zurita,; Smith, Pamela; Vallejos, Carla; Aguillón Gutiérrez, Juan Carlos; Lopez, Mauricio; Ferreira e Ferreira, Efigenia (1995)
      The bovine model is extremely interesting to study several basic aspects of mucosal local immunity. Many reports have shown that, in young calves, the infectivity of enterotoxigenic Escherichia coli may be inhibited by ...
    • Immunosuppressive Mechanisms of Regulatory B Cells 
      Catalán Martina, Diego Francisco; Mansilla, Miguel Andrés; Ferrier Espósito, Ashley Andrés; Soto, Lilian; Oleinika, Kristine; Aguillón Gutiérrez, Juan Carlos; Aravena, Octavio (Frontiers Media, 2021)
      Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing immune responses and reestablishing immune ...
    • Mild hypothermia upregulates myc and xbp1s expression and improves anti TNF alpha production in CHO cells 
      Torres, Mauro; Zúniga, Roberto; Gutiérrez, Matias; Vergara, Mauricio; Collazo, Norberto; Reyes, Juan; Berrios, Julio; Aguillón Gutiérrez, Juan Carlos; Molina Sampayo, María Carmen; Altamirano, Claudia (Public Library Science, 2018)
      Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins. However, their low protein productivity in culture is the main hurdle to overcome. Mild hypothermia has ...
    • Modulation of established murine collagen-induced arthritis by a single inoculation of short-term ... 
      Salazar, L.; Aravena, O.; Abello, P.; Escobar, A.; Contreras Levicoy, Juan; Rojas Colonelli, Nicole; Catalán Martina, Diego; Aguirre A., Luz María; Zúñiga, R.; Pesce Reyes, Bárbara; González, C.; Cepeda, R.; Cuchacovich Turteltaub, Miguel; Molina, M. C.; Salazar Onfray, Flavio; Delgado, M.; Toes, R. E.; Aguillón Gutiérrez, Juan Carlos (2008)
      Background: The use of regulatory or immature dendritic cells (DCs) as tools for modulating experimental rheumatoid arthritis is very recent. Tumour necrosis factor (TNF)-stimulated DCs have been shown to restore tolerance ...
    • Octadecyl silica: A solid phase for protein purification by immunoadsorption 
      Chiong Lay, Mario; Lavandero González, Sergio; Ramos, Rodrigo; Aguillón Gutiérrez, Juan Carlos; Ferreira, Arturo (1991)
      Immunoaffinity chromatography involves binding of an antigen or antibody to a solid matrix, usually agarose, frequently using the cyanogen bromide method. These methods are laborious, rather expensive, and their use has ...
    • Purification and preliminary sequencing of Tc45, an immunodominant Trypanosoma cruzi antigen: Absence of ... 
      Aguillón Gutiérrez, Juan Carlos; Bustos,; Vallejos, Carla; Hermosilla, Manuel; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Hellman,; Orn,; Ferreira e Ferreira, Efigenia (American Society of Tropical Medicine and Hygiene, 1995)
      In spite of being separated by more than 20 million years of evolution, the murine and human immune systems share extensive similarities. Thus, experimental results obtained with the murine model may have predictive value ...
    • Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo 
      Campos Acuña, Javier; Pérez, Francisco; Narváez, Edgar; Campos Mora, Mauricio; Gajardo, Tania; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos; Pino Lagos, Karina (Future Medicine, 2015)
      Aim: To date, there is no human dendritic cell (DC) based therapy to prevent allograft rejection in transplanted patients. Here, we evaluate a potential protocol using a murine in vivo transplant model. Materials & ...
    • Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine ... 
      Morales, Rodrigo A.; Campos Mora, Mauricio; Gajardo, Tania; Pérez, Francisco; Campos, Javier; Aguillón Gutiérrez, Juan Carlos; Pino-Lagos, Karina (Elsevier GmbH, 2015)
      © 2014 Elsevier GmbH.Retinoic acid (RA), a vitamin A metabolite, has been attributed to relevant functions in adaptive immunity. On T cells, the disruption on RA signaling alters both CD4+ and CD8+ T cells effector function. ...
    • Rol terapéutico de Células Dendríticas reguladoras en el modelo murino de artritis mediante evaluación ... 
      Peña Jiménez, María Corina (Universidad de Chile, 2013)
      La artritis reumatoide (AR) es la enfermedad articular inflamatoria más común que afecta al 1% de la población mundial, de causas multifactoriales, poligénica y autoinmune. Se caracteriza por inflamación articular crónica ...
    • Soybean proteins: Alternative blocking agents for immunoassays using nitrocellulose or plastic solid phases 
      Aguillón Gutiérrez, Juan Carlos; Chiong Chiong, Jade María; Ramos Ramos,Fernanda C.; Vallejos, Carla; Ferreira e Ferreira, Efigenia (1992)
      The values of soybean proteins (SBP) and bovine serum albumin (BSA) as blocking agents were compared in immunoradiometric (IRMA), western immunoblotting (WIBA) and immunodot (IDA) assays. Protein purification, from soybean ...
    • TNF-alpha affects signature cytokines of th1 and th17 t cell subsets through differential actions on TNFR1 ... 
      Pesce Reyes, Bárbara Paz; Ribeiro, Carolina Hager; Larrondo Lillo, Milton Leonel; Ramos, Verónica; Soto Sáez, Lilian Andrea; Catalán Martina, Diego Francisco; Aguillón Gutiérrez, Juan Carlos (MDPI, 2022)
      Tumor necrosis factor (TNF)- is a pleiotropic cytokine implicated in the etiology of several autoimmune diseases, including rheumatoid arthritis (RA). TNF- regulates diverse effector functions through the activation ...